Recent Publications

Shan, C., Wang, J., Xu, K., Chen, H., Yue, J., Andrews, S., Moresco, J.J., Yates, J.R., Nagy, P.L., Tong, L., and Jia, S. (2016). A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. Elife Doi: 10.7554/eLife.17903.
Wang, J., Jia, S.T., and Jia, S. (2016). New Insights into the regulation of heterochromatin. Trends in Genetics 32(5): 284-94.
Wang, J., Cohen, A.L., Letian, A., Tadeo, X., Moresco, J.J., Liu, J., Yates, J.R., Qiao, F., and Jia, S. (2016). The proper connection between shelterin components is required for telomeric heterochromatin assembly. Genes Dev. 30(7): 827-39.
Wang, J., Reddy, B.D., and Jia, S. (2015). Rapid epigenetic adaptation to uncontrolled heterochromatin spreading. Elife doi:10.7554/elife.06179.
Wang, J., Tadeo, X., Hou, H., Andrews, S., Moresco, J.J., Yates, J.R., Nagy, P.L., and Jia, S. (2014). Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length. Nucleic Acids Res. 42(18): 11419-32.
Wang, J., Lawry, S.T., Cohen, A.L. and Jia, S. (2014). Chromosome boundary elements and regulation of heterochromatin spreading. Cell Mol. Life Sci. 71(24): 4841-52.
Cohen, A.L. and Jia, S. (2014). Non-coding RNAs and the borders of heterochromatin. Wiley Interdiscip. Rev. RNA 5(6):835-47.
Kallgren, S.P., Andrews, S., Tadeo, X., Hou, H., Moresco, J.J, Tu, P.G., Yates, J.R., Nagy, P., and Jia, S. (2014). The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast. PLoS Genet. 10(5):e1004334.
Tadeo, X., Wang, J., Kallgren, S.P., Liu, J., Reddy, B.D., Quio, F., and Jia, S. (2013). Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly. Genes Dev. 27(22): 2489-99.
Wang, J., Tadeo, X., Hou, H., Tu, P.G., Thompson, J., Yates, J.R., and Jia, S. (2013). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries. Genes Dev. 27(17): 1886-902.
Hou, H., Kallgren, S.P., and Jia, S. (2013). Csi1 illuminates the mechanism and function of Rabl configuration. Nucleus 4(3): 176-81.
Hou, H., Zhou, Z., Wang, Y., Wang, J., Kallgren, S.P., Kurchuk, T., Miller, E.A., Chang, F., and Jia, S. (2012) Csi1 links centromeres to the nuclear envelope for centromere clustering. J. Cell Biol. 199(5): 735-44.
Wang, Y., Kallgren, S., Reddy, B.D., Kuntz, K., Lopez-Maury, L., Thompson, J., Watt, S., Ma, C., Hou, H., Shi, Y., Yates, J.R., Bahler, J., O'Connell, M.J. and Jia, S. (2012) Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast. J. Biol. Chem. 287(6): 4386-93.
Reddy, B.D., Wang, Y., Niu, L., Higuchi, E.C., Marguerat, S.B., Bahler, J., Smith, G.R. and Jia, S. (2011) Elimination of a specific histone H3K14 acetyltransferase complex bypasses the RNAi pathway to regulate pericentric heterochromatin functions. Genes. Dev. 25(3): 214-9.
Hou, H., Wang, Y., Kallgren, S.P., Thompson, J., Yates, J.R. and Jia, S. (2010) Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast. J. Biol. Chem. 285(3): 1909-18.
Wang, Y. and Jia, S. (2009) Degrees make all the difference: the multifunctionality of histone H4 lysine 20 methylation. Epigenetics 4(5): 1-4.
Wang, Y., Reddy, B.D., Thompson, J., Wang, H., Noma, K., Yates, J.R. and Jia, S. (2009) Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein. Mol. Cell 33(4): 428-37.
Reddy, B.D. and Jia, S. (2008) Heterochromatin: lost in transcription? Cell Cycle 7(22): 3479-80.
Grewal, S.I. and Jia, S. (2007) Heterochromatin revisited. Nat. Rev. Genet. 8(1): 35-46.


Before coming to Columbia

Ratnaparkhi, G.S., Jia, S., and Courey, A.J. (2006) Uncoupling Dorsal-mediated activation from Dorsal-mediated repression in the Drosophila embryo. Development 133(22): 4409-14.
Jia, S., Kobayashi, R., and Grewal, S.I. (2005) Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin. Nat. Cell Biol. 7(10): 1007-13.
Hasson, P., Egoz, M., Winkler, C., Volohonsky, G., Jia, S., Dinur, T., Volk, T., Courey, A.J. and Paroush, Z. (2005) EGFR signaling attenuates Groucho-dependent repression to antagonize Notch transcriptional output. Nat. Genet. 37(1): 101-5.
Jia, S., Yamada, T. and Grewal S.I. (2004) Heterochromatin regulates cell type-specific long-range chromatin interactions essential for directed recombination. Cell 119(4): 469-80.
Noma, K., Sugiyama, T., Cam, H., Verdel, A., Zofall, M., Jia, S., Moazed, D. and Grewal S.I. (2004) RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Nat. Genet. 36(11): 1174-80.
Jia, S., Noma, K. and Grewal, S.I. (2004) RNAi- independent heterochromatin nucleation by the stress-activated ATF/ CREB family proteins. Science 304(5679): 1971-6.
Verdel, A., Jia, S., Gerber, S., Sugiyama, T., Gygi, S., Grewal, S.I. and Moazed, D (2004) RNAi-mediated targeting of heterochromatin by the RITS complex. Science 303(5658): 672-6.
Jia, S. Flores-Saaib, R.D. and Courey, A.J. (2002) The Dorsal rel homology domain plays an active role in transcriptional regulation. Mol. Cell. Biol. 22(14): 5089-99.
Courey, A.J. and Jia, S. (2001) Transcriptional repression: the long and the short of it. Genes Dev. 15(21): 2786-96.
Flores-Saaib, R.D., Jia, S., and Courey, A.J. (2001) Activation and repression by the C-terminal domain of Dorsal. Development 128(10): 1869-79.